Holliday Junction Thermodynamics and Structure: Coarse-Grained Simulations and Experiments
نویسندگان
چکیده
منابع مشابه
Holliday Junction Thermodynamics and Structure: Coarse-Grained Simulations and Experiments
Holliday junctions play a central role in genetic recombination, DNA repair and other cellular processes. We combine simulations and experiments to evaluate the ability of the 3SPN.2 model, a coarse-grained representation designed to mimic B-DNA, to predict the properties of DNA Holliday junctions. The model reproduces many experimentally determined aspects of junction structure and stability, ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep22863